Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

ABSTRACT: Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants play a role in the etiology of schizophrenia, most of the currently explained liability is within common variation, suggesting that variation predating the human diaspora out of Africa harbors a large fraction of the common variant attributable heritability. However, common variant association studies in schizophrenia have concentrated mainly on cohorts of European descent. We describe genome-wide association studies of 6152 cases and 3918 controls of admixed African ancestry, and of 1234 cases and 3090 controls of Latino ancestry, representing the largest such study in these populations to date. Combining results from the samples wi

SUBMITTER: Bigdeli TB 

PROVIDER: S-EPMC7515843 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature