Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner.

ABSTRACT: Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result

SUBMITTER: Vasistha NA 

PROVIDER: S-EPMC7515848 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature