Quantification of regional murine ozone-induced lung inflammation using [¹⁸F]F-FDG microPET/CT imaging.

ABSTRACT: Ozone (O₃) is a highly potent and reactive air pollutant. It has been linked to acute and chronic respiratory diseases in humans by inducing inflammation. Our studies have found evidence that 0.05 ppm of O₃, within the threshold of air quality standards, is capable of inducing acute lung injury. This study was undertaken to examine O₃-induced lung damage using [¹⁸F]F-FDG (2-deoxy-2-[¹⁸F]fluoro-D-glucose) microPET/CT in wild-type mice. [¹⁸F]F-FDG is a known PET tracer for inflammation. Sequential [¹⁸F]F-FDG microPET/CT was performed at baseline (i.e. before O₃ exposure), immediately (0 h), at 24 h and at 28 h following 2 h of 0.05 ppm O₃ exposure. The images were quantified to determine O

SUBMITTER: Aulakh GK 

PROVIDER: S-EPMC7515916 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature