Clinical translation of ¹⁸F-fluoropivalate - a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers.

ABSTRACT:

Background

Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including ¹¹C-acetate, and ¹⁸F-FAC (2-¹⁸F-fluoroacetate), have previously been used to study short-chain fatty acid (SCFA) metabolism. We developed ¹⁸F-fluoropivalate (¹⁸F-FPIA; 3-¹⁸F-fluoro-2,2-dimethylpropionic acid) bearing a gem-dimethyl substituent to assert metabolic stability for studying SCFA metabolism. We report the safety, biodistribution, and internal radiation dosimetry profile of ¹⁸F-FPIA in 24 healthy volunteers and the effect of dietary conditions.

Materials and methods

Healthy volunteer male and female subjects we

SUBMITTER: Dubash SR 

PROVIDER: S-EPMC7515955 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature