Dynamic Changes in the Phenotype of Dendritic Cells in the Uterus and Uterine Draining Lymph Nodes After Coitus.

ABSTRACT: Dendritic cells (DCs) are essential for successful embryo implantation. However, the properties of uterine DCs (uDCs) during the implantation period are not well characterized. In this study, we investigated the dynamic changes in the uDC phenotypes during the period between coitus and implantation. In virgin mice, we evaluated the expressions of CD103 and XCR1, this is the first report to demonstrate uDCs expressing CD103 in XCR1⁺cDC1s and XCR1⁺cDC2s. On day 0.5 post coitus (pc), the number of uterine CD11c⁺CD103^-MHC classII^highCD86^high-mature DCs rapidly increased and then decreased to non-pregnancy levels on days 1.5 and 2.5 pc. On day 3.5 pc just before implantation, the number of CD11c⁺CD103⁺MHC cl

SUBMITTER: Yasuda I 

PROVIDER: S-EPMC7516021 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature