Antidepressant drug use in glioblastoma patients: an epidemiological view.

ABSTRACT:

Background

Antidepressant drugs have shown antitumor activity in preclinical glioblastoma studies. Antidepressant drug use, as well as its association with survival, in glioblastoma patients has not been well characterized on a population level.

Methods

Patient characteristics, including the frequency of antidepressant drug use, were assessed in a glioblastoma cohort diagnosed in a 10-year time frame between 2005 and 2014 in the Canton of Zurich, Switzerland. Cox proportional hazards regression models were applied for multivariate analysis. Kaplan-Meier survival curves were used to estimate overall survival (OS) data and the log-rank test was performed for comparisons.

Results

A total of 404 patients with isocitrate dehydrogenase wild-type glioblastoma were included i

SUBMITTER: Gramatzki D 

PROVIDER: S-EPMC7516105 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature