Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review.

ABSTRACT: The optimal management strategy for patent ductus arteriosus in preterm infants remains a topic of debate. Available evidence for a treatment strategy might be biased by the delayed spontaneous closure of the ductus arteriosus in preterm infants, which appears to depend on patient characteristics. We performed a systematic review of all literature on PDA studies to collect patient characteristics and reported numbers of patients with a ductus arteriosus and spontaneous closure. Spontaneous closure rates showed a high variability but were lowest in studies that only included preterm infants with gestational ages below 28 weeks or birth weights below 1,000 g (34% on day 4; 41% on day 7) compared to studies that also included infants with higher gestational ages or higher birth weights (up to

SUBMITTER: de Klerk JCA 

PROVIDER: S-EPMC7516116 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature