Spatiotemporal control of gene expression boundaries using a feedforward loop.

ABSTRACT:

Background

A feedforward loop (FFL) is commonly observed in several biological networks. The FFL network motif has been mostly studied with respect to variation of the input signal in time, with only a few studies of FFL activity in a spatially distributed system such as morphogen-mediated tissue patterning. However, most morphogen gradients also evolve in time.

Results

We studied the spatiotemporal behavior of a coherent FFL in two contexts: (a) a generic, oscillating morphogen gradient and (b) the dorsal-ventral patterning of the early Drosophila embryo by a gradient of the NF-κB homolog dorsal with its early target Twist. In both models, we found features in the dynamics of the intermediate node-phase difference and noise filtering-that were largely independent of the par

SUBMITTER: Bandodkar PU 

PROVIDER: S-EPMC7516927 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature