A Nosocomial Respiratory Infection Outbreak of Carbapenem-Resistant <i>Escherichia coli</i> ST131 With Multiple Transmissible <i>bla</i> _<i>KPC-</i>2 Carrying Plasmids.

ABSTRACT: Escherichia coli sequence type 131 (ST131) is well known for its multidrug resistance profile. Carbapenems have been considered the treatment of choice for E. coli ST131 infections, and resistance to carbapenems is emerging due to the acquisition of carbapenemase-encoding genes. In this study, 45 carbapenem-resistant E. coli strains were collected in a hospital. The resistance mechanisms, plasmid profiles, and genetic relatedness of these strains were determined. Phylogenetic relationships between these strains were assessed by molecular profiling and aligned with patient clinical details. The genetic context of bla _KPC-2 was analyzed to trace the potential dissemination of bla _KPC-2. The 45 carbapenem-resistant E. c

SUBMITTER: Gong L 

PROVIDER: S-EPMC7516988 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature