Administration of Extensive Hydrolysates From Caseins and Lactobacillus rhamnosus GG Probiotic Does Not Prevent Cow's Milk Proteins Allergy in a Mouse Model.

ABSTRACT:

Background

Early nutrition may influence the development of food allergies later in life. In the absence of breastfeeding, hydrolysates from cow's milk proteins (CMP) were indicated as a prevention strategy in at risk infants, but their proof of effectiveness in clinical and pre-clinical studies is still insufficient. Thanks to a validated mouse model, we then assessed specific and nonspecific preventive effects of administration of extensive hydrolysates from caseins (eHC) on the development of food allergy to CMP. The additional nonspecific effect of the probiotic Lactobacillus GG (LGG), commonly used in infant formula, was also assessed.

Methods

Groups of young BALB/cByJ female mice were pretreated by repeated gavage either with PBS (control mice), or with PBS solu

SUBMITTER: Adel-Patient K 

PROVIDER: S-EPMC7516991 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature