Association between MTHFR C677T/A1298C and susceptibility to autism spectrum disorders: a meta-analysis.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is becoming increasingly prevalent of late. Methylenetetrahydrofolate reductase (MTHFR) has a significant role in folate metabolism. Owing to the inconsistencies and inconclusiveness on the association between MTHFR single nucleotide polymorphism (SNP) and ASD susceptibilities, a meta-analysis was conducted to settle the inconsistencies.

Methods

For this meta-analysis, a total of 15 manuscripts published up to January 26, 2020, were selected from PubMed, Google Scholar, Medline, WangFang, and CNKI databases using search terms "MTHFR" OR "methylenetetrahydrofolate reductase" AND "ASD" OR "Autism Spectrum Disorders" OR "Autism" AND "polymorphism" OR "susceptibility" OR "C677T" OR "A1298C".

Results

The findings of the meta-analys

SUBMITTER: Li Y 

PROVIDER: S-EPMC7517654 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature