Exploration of CYP21A2 and CYP17A1 polymorphisms and preeclampsia risk among Chinese Han population: a large-scale case-control study based on 5021 subjects.

ABSTRACT:

Background

Several genome-wide association studies have identified single-nucleotide polymorphisms (SNPs), such as rs4409766, rs1004467, and rs3824755 in CYP17A1 and rs2021783 in CYP21A2, as new hypertension susceptibility genetic variants in the Chinese population. This study aimed to look into the relationship between preeclampsia (PE) and these SNPs in Chinese Han women.

Methods

Overall, 5021 unrelated pregnant women were recruited, including 2002 patients with PE and 3019 normal healthy controls. The real-time PCR (TaqMan) method was applied to genotype these four polymorphisms.

Results

A statistically obvious difference in the allelic frequencies was observed in CYP21A2 rs2021783 between cases and controls (χ² = 7.201, Pc = 0.028 by allele), and the T

SUBMITTER: Hou B 

PROVIDER: S-EPMC7517682 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature