The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue.

ABSTRACT:

Background

Lung cancer is a leading cause of cancer morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection is an important risk factor in the development of lung cancer. In this study, we aim to address the role of HPV in the development of lung cancer mechanistically by examining the induction of inflammation and epithelial-mesenchymal transition (EMT) by this virus.

Methods

In this case-control study, tissue samples were collected from 102 cases with lung cancer and 48 controls. We examined the presence of HPV DNA and also the viral genotype in positive samples. We also examined the expression of viral genes (E2, E6 and E7), anti-carcinogenic genes (p53, retinoblastoma (RB)), and inflammatory cytokines in HPV positive ca

SUBMITTER: Rezaei M 

PROVIDER: S-EPMC7517685 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature