Effective connectivity between Broca's area and amygdala as a mechanism of top-down control in worry.

ABSTRACT: Individuals higher in trait worry exhibit increased activation in Broca's area during inhibitory processing tasks. To identify whether such activity represents an adaptive mechanism supporting top-down control, functional and effective connectivity of Broca's area were investigated during a task of inhibitory control. fMRI data obtained from 106 participants performing an emotion-word Stroop task were examined using psychophysiological interaction and Granger Causality (GC) analyses. Findings revealed greater directed connectivity from Broca's to amygdala in the presence of emotional distraction. Furthermore, a predictive relationship was observed between worry and the asymmetry in effective connectivity, with worriers exhibiting greater directed connectivity from Broca's to amygdala. When

SUBMITTER: Guha A 

PROVIDER: S-EPMC7517719 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature