Acquired factor V inhibitors after allogeneic hematopoietic stem cell transplantation in a dog.

ABSTRACT:

Objective

Describe the clinical course and management of a dog that underwent hematopoietic stem cell transplantation (HSCT) for treatment of B-cell lymphoma and developed acquired circulating factor V (FV) inhibitors.

Case summary

An 8-year-old male castrated Briard dog diagnosed with lymphoma (IVb, B-cell) presented for allogeneic HSCT. Despite multiple platelet, fresh frozen plasma, and red blood cell transfusions prolonged recovery and clinical bleeding occurred. Circulating acquired FV inhibitors were identified and hemorrhage subsequently was managed by immunosuppression. The dog was discharged when clinical resolution of bleeding was achieved.

New or unique information provided

This case report describes a dog undergoing curative intent treatment for lymphoma,

SUBMITTER: Masciana J 

PROVIDER: S-EPMC7517841 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature