Genetic and environmental risk for lymphoma in boxer dogs.

ABSTRACT:

Background

Non-Hodgkin lymphoma in humans is associated with environmental chemical exposures, and risk is enhanced by genetic variants in glutathione S-transferases (GST) enzymes.

Objective

We hypothesized that boxer dogs, a breed at risk for lymphoma, would have a higher prevalence of GST variants with predicted low activity, and greater accumulated DNA damage, compared to other breeds. We also hypothesized that lymphoma in boxers would be associated with specific environmental exposures and a higher prevalence of canine GST variants.

Animals

Fifty-four healthy boxers and 56 age-matched nonboxer controls; 63 boxers with lymphoma and 89 unaffected boxers ≥10 years old.

Methods

We resequenced variant loci in canine GSTT1, GSTT5, GSTM1, and GSTP1 and compared en

SUBMITTER: Craun K 

PROVIDER: S-EPMC7517848 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature