Dataset Information

Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

ABSTRACT:

Background

Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion.

Objectives

Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death.

Animals

Thirty-one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs.

Methods

Antithrombin and α₂ -antiplasmin activity (ATA and α₂ AP, respectively) and concentrations of α₁ -proteinase inhibitor (α₁ PI), α₂ -macroglobulin (α₂ MG), C-reactive protein (CRP), interleukins (ILs)-2,6,8 and tumor necrosis factor-α (TNF-α) were prospectively measured. Severity of AP was assessed by clinical severity scoring systems.

Results

Mortality rate was 19%. Antithrombin activity was lower (P = .004) and maximal CRP, IL-6, and TNF-α concentrations higher (P < .04) in the AP group compared to the controls, whereas IL-2, IL-8, α₁ PI, and α₂ AP concentrations did not differ between groups. Serum α₂ MG concentration was not reliably detected. Serum cPLI, CRP, and IL-6 concentrations were significantly and positively correlated. The ATA was lower (P = .04), and canine acute pancreatitis severity (CAPS) scores higher (P = .009) in nonsurvivors compared to survivors. Higher CAPS scores were associated (P < .05) with decreased ATA and increased cPLI, CRP, and IL-6 concentrations.

Conclusions and clinical importance

Systemic inflammation in dogs with AP is manifested by increased inflammatory mediator concentrations, correlating with cPLI and CRP concentrations. Hypoantithrombinemia is associated with death. Serum concentrations of α₂ AP and α₁ PI are less useful prognostic markers. The CAPS score is a useful prognostic marker in dogs with AP.

SUBMITTER: Kuzi S

PROVIDER: S-EPMC7517856 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

Kuzi Sharon S Mazaki-Tovi Michal M Suchodolski Jan S JS Rimer Dar D Lidbury Jonathan A JA Steiner Joerg M JM Buono Agostino A Nivy Ran R Segev Gilad G Aroch Itamar I

Journal of veterinary internal medicine 20200907 5

<h4>Background</h4>Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion.<h4>Objectives</h4>Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death.<h4>Animals</h4>Thirty-one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs.<h4>Method ...[more]

PMID: 32893923

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Dataset Information

Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

Background

Objectives

Animals

Methods

Results

Conclusions and clinical importance

Publications

Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

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