Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis.

ABSTRACT:

Background

Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion.

Objectives

Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death.

Animals

Thirty-one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs.

Methods

Antithrombin and α₂ -antiplasmin activity (ATA and α₂ AP, respectively) and concentrations of α₁ -proteinase inhibitor (α₁ PI), α₂ -macroglobulin (α₂ MG), C-reactive protein (CRP), interleukins (ILs)-2,6,8 and tumor necrosis fac

SUBMITTER: Kuzi S 

PROVIDER: S-EPMC7517856 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature