Altered lung tissue lipidomic profile in caspase-4 positive non-small cell lung cancer (NSCLC) patients.

ABSTRACT: Lung cancer is by far the leading cause of cancer death. Metabolomic studies have highlighted that both tumor progression and limited curative treatment options are partly due to dysregulated glucose metabolism and its associated signaling pathways. In our previous studies, we identified caspase-4 as a novel diagnostic tool for non-small cell lung cancer (NSCLC). Here, we analyzed the metabolomic profile of both plasma and tumor tissues of NSCLC patients stratified as caspase-4 positive or negative. We found that circulating caspase-4 was correlated to LDH. However, this effect was not observed in caspase-4 positive tumor tissues, where instead, fatty acid biosynthesis was favoured in that the malonic acid and the palmitic acid were higher than in non-cancerous and caspase-4 negative tissu

SUBMITTER: Terlizzi M 

PROVIDER: S-EPMC7517963 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature