Standardized algorithm for muscle selection and dosing of botulinum toxin for Parkinson tremor using kinematic analysis.

ABSTRACT:

Background

Inadequate efficacy and significant side effect profile makes pharmacological treatment of Parkinson's disease (PD) tremor challenging. Personalized dosing of botulinum toxin type A (BoNT-A) using tremor analysis has shown efficacy and safety for treating upper limb tremor. This study incorporated a novel, standardized treatment algorithm for determining injection pattern and BoNT-A dosing, customizable by the physician, in PD patients with disabling tremor in one or both arms.

Methods

This open-label study included 47 PD participants (25 "De-novo" and 22 "L-dopa") who received 4 serial BoNT-A treatments with follow-ups at 6 weeks post-treatment over 42 weeks. The treatment algorithm utilized kinematic tremor analysis of each participant's whole arm tremor and det

SUBMITTER: Samotus O 

PROVIDER: S-EPMC7517980 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature