Myrcene exerts anti-asthmatic activity in neonatal rats via modulating the matrix remodeling.

ABSTRACT: Myrcene (MC), an organic hydrocarbon, was found to exert anti-inflammatory, analgesic, antimutagenic and antioxidant properties. However, the protective role of MC has not been reported against neonatal asthma. Wistar rats induced with asthma were administered with MC; while asthma control and vehicle control were maintained without MC administration. At the end of the experimental period, lung histology, inflammatory cell counts, cytokine analysis, matrix protein expressions were elucidated. Rats administered with MC exerted significant (P < 0.05) defense in protecting the lung tissue with the evidenced restoration of alveolar thickening of the lung tissues. Also, the present study elicited the anti-asthmatic activity of MC, especially via modulating the extracellular matrix protei

SUBMITTER: Du Y 

PROVIDER: S-EPMC7517990 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature