Clinicopathologic significance of nuclear HER4 and phospho-YAP(S¹²⁷) in human breast cancers and matching brain metastases.

ABSTRACT:

Background

Human epidermal growth factor receptor-4 (HER4) and yes-associated protein-1 (YAP) are candidate therapeutic targets in oncology. YAP's transcriptional coactivation function is modulated by the HER4 intracellular domain (HER4-ICD) in vitro, but the clinical relevance of this has not been established. This study investigated the potential for targeting the HER4-YAP pathway in brain metastatic breast cancer.

Methods

We performed immuno-phenotypic profiling of pathway markers in a consecutive breast cancer series with 25 years of clinical follow up (n = 371), and patient-matched breast and metastatic brain tumours (n = 91; 30 pairs).

Results

Membrane localisation of phospho-HER4 [pHER4(Y¹¹⁶²)] was infrequent in primary breast ca

SUBMITTER: Kalita-de Croft P 

PROVIDER: S-EPMC7517995 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature