Computational Tools for Evaluating Phylogenetic and Hierarchical Clustering Trees.

ABSTRACT: Inferential summaries of tree estimates are useful in the setting of evolutionary biology, where phylogenetic trees have been built from DNA data since the 1960s. In bioinformatics, psychometrics, and data mining, hierarchical clustering techniques output the same mathematical objects, and practitioners have similar questions about the stability and "generalizability" of these summaries. This article describes the implementation of the geometric distance between trees developed by Billera, Holmes, and Vogtmann (2001) equally applicable to phylogenetic trees and hierarchical clustering trees, and shows some of the applications in evaluating tree estimates. In particular, since Billera et al. (2001) have shown that the space of trees is negatively curved (called a CAT(0) space), a collection

SUBMITTER: Chakerian J 

PROVIDER: S-EPMC7518125 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature