Multi-omics analysis identifies FoxO1 as a regulator of macrophage function through metabolic reprogramming.

ABSTRACT: Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated that the transcription factor Forkhead Box Protein 1 (FoxO1) plays a pivotal role in regulating the function of macrophages, but the underlying mechanisms are still unclear. Here we identify FoxO1 as a regulator of macrophage function through metabolic reprogramming. Transcriptomic and proteomic analyses showed that the deficiency of FoxO1 results in an alternatively activated (M2) phenotype of macrophages, with lower expression of inflammatory response- and migration-associated genes. Using the high content screening and analysis technology, we found that deletion of FoxO1 in macrophages slows their migration rate and impairs their fun

SUBMITTER: Yan K 

PROVIDER: S-EPMC7518254 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature