Serum proteins may facilitate the identification of Kawasaki disease and promote in vitro neutrophil infiltration.

ABSTRACT: Kawasaki disease (KD) usually affects the children younger than 5 years of age and subsequently causes coronary artery lesions (CALs) without timely identification and treatment. Developing a robust and fast prediction method may facilitate the timely diagnosis of KD, significantly reducing the risk of CALs in KD patients. The levels of inflammatory serum proteins dramatically vary during the onsets of many immune diseases, including in KD. However, our understanding of their pathogenic roles in KD is behind satisfaction. The purpose of this study was to evaluate candidate diagnostic serum proteins and the potential mechanism in KD using iTRAQ gel-free proteomics. We enrolled subjects and conducted iTRAQ gel-free proteomics to globally screen serum proteins followed by specific validation

SUBMITTER: Li SC 

PROVIDER: S-EPMC7518260 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature