Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.

ABSTRACT: Prevailing strategies in genome-wide association studies (GWAS) mostly rely on principles of medical genetics emphasizing one gene, one function, one phenotype concept. Here, we performed GWAS of blood lipids leveraging a new systemic concept emphasizing complexity of genetic predisposition to such phenotypes. We focused on total cholesterol, low- and high-density lipoprotein cholesterols, and triglycerides available for 29,902 individuals of European ancestry from seven independent studies, men and women combined. To implement the new concept, we leveraged the inherent heterogeneity in genetic predisposition to such complex phenotypes and emphasized a new counter intuitive phenomenon of antagonistic genetic heterogeneity, which is characterized by misalignment of the directions of genetic

SUBMITTER: Kulminski AM 

PROVIDER: S-EPMC7518561 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature