Biomarkers Associated with Physical Resilience After Hip Fracture.

ABSTRACT:

Background

Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derived a measure of physical resilience after hip fracture-the expected recovery differential (ERD)-that captures the difference between actual recovery and predicted recovery. Starting with biomarkers associated with physical performance, morbidity, mortality, and hip fracture, we evaluated associations with the ERD to identify biomarkers of physical resilience after hip fracture.

Methods

In the Baltimore Hip Studies (N = 304) sera, we quantified biomarkers of inflammation (TNFR-I, TNFR-II, sVCAM-1, and IL-6), metabolic and mito

SUBMITTER: Parker DC 

PROVIDER: S-EPMC7518564 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature