Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus.

ABSTRACT: Porcine rubulavirus (PRV), which belongs to the family Paramyxoviridae, causes blue eye disease in pigs, characterized by encephalitis and reproductive failure in newborn and adult pigs, respectively. There is no effective treatment against PRV and no information on the effectiveness of the available vaccines. Continuous outbreaks have occurred in Mexico since the early 1980s, which have caused serious economic losses to pig producers. Vaccination can be used to control this disease. Searching for effective antigen candidates against PRV, we first sequenced the PAC1 F protein, then we used various immunoinformatics tools to predict antigenic determinants of B-cells and T-cells against the two glycoproteins of the virus (HN and F proteins). Finally, we used AutoDock Vina to determine the bi

SUBMITTER: Sianez-Estrada LI 

PROVIDER: S-EPMC7518572 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature