Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report.

ABSTRACT:

Background

The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer's TNM classification (TNM8), where depth of invasion (DOI) supplements diameter in the tumor size (T) categorization.

Methods

Patients diagnosed with primary oral tongue squamous cell carcinoma were evaluated retrospectively. Spearman bivariate correlation analyses with bootstrapping were used to identify correlation between variables. Prognostic value of clinical and histopathological variables was assessed by Log rank a

SUBMITTER: Bjerkli IH 

PROVIDER: S-EPMC7518591 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature