A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML.

ABSTRACT: Translocations of the KMT2A (MLL) gene define a biologically distinct and clinically aggressive subtype of acute myeloid leukaemia (AML), marked by a characteristic gene expression profile and few cooperating mutations. Although dysregulation of the epigenetic landscape in this leukaemia is particularly interesting given the low mutation frequency, its comprehensive analysis using whole genome bisulphite sequencing (WGBS) has not been previously performed. Here we investigated epigenetic dysregulation in nine MLL-rearranged (MLL-r) AML samples by comparing them to six normal myeloid controls, using a computational method that encapsulates mean DNA methylation measurements along with analyses of methylation stochasticity. We discovered a dramatically altered epigenetic profile in MLL

SUBMITTER: Koldobskiy MA 

PROVIDER: S-EPMC7518694 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature