Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitamin K1) supplementation.

ABSTRACT: Evidence suggests there are roles for vitamin K in various chronic disease outcomes, but population-level diet and supplement recommendations are difficult to determine due to high levels of variability in measures of status and response to intake compared to other nutrients. In this preliminary investigation, a blood-based epigenome-wide association study (EWAS) comparing responders and non-responders to phylloquinone (vitamin K1) supplementation (NCT00183001) was undertaken in order to better understand the molecular underpinnings of this observed variability. Responders (n = 24) and non-responders (n = 24) were identified in a prior 3-year phylloquinone supplementation trial based on their changes in plasma phylloquinone concentrations. Differential DNA methylation was identified in mul

SUBMITTER: Westerman K 

PROVIDER: S-EPMC7518702 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature