Endosialin defines human stem Leydig cells with regenerative potential.

ABSTRACT:

Study question

Is endosialin a specific marker of human stem Leydig cells (SLCs) with the ability to differentiate into testosterone-producing Leydig cells (LCs) in vitro and in vivo?

Summary answer

Endosialin is a specific marker of human SLCs which differentiate into testosterone-producing LCs in vitro and in vivo.

What is known already

Human SLCs have been identified and isolated using the marker platelet-derived growth factor receptor α (PDGFRα) or nerve growth factor receptor (NGFR). However, the specificity was not high; thus, LCs and germ cells could be mistakenly sorted as SLCs if PDGFRα or NGFR was used as a marker for human SLCs isolation.

Study design, size, duration

Firstly, we re-evaluated the specificity of PDGFRα and NGFR for SLCs in adult human

SUBMITTER: Xia K 

PROVIDER: S-EPMC7518712 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature