Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.

ABSTRACT: The topology of the cerebral cortex has been proposed to provide an important source of constraint for the organization of cognition. In a sample of twins (n = 1113), we determined structural covariance of thickness to be organized along both a posterior-to-anterior and an inferior-to-superior axis. Both organizational axes were present when investigating the genetic correlation of cortical thickness, suggesting a strong genetic component in humans, and had a comparable organization in macaques, demonstrating they are phylogenetically conserved in primates. In both species, the inferior-superior dimension of cortical organization aligned with the predictions of dual-origin theory, and in humans, we found that the posterior-to-anterior axis related to a functional topography describi

SUBMITTER: Valk SL 

PROVIDER: S-EPMC7518868 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature