New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo.

ABSTRACT: Several biologically active bivalent Pd and Pt complexes with two structurally similar cyanoxime ligands abbreviated as H(DECO): 2-oximino-2-cyano-N,N'-diethylacetamide, and H(PyrCO): 2-oximino-2-cyan-N-pyrrolidine acetamide were synthesized and characterized using spectroscopic methods, thermal analysis and X-ray crystallography. Structures revealed planar cis-geometry of studied complexes. Freshly obtained Pt(DECO)₂, Pd(DECO)₂, Pt(PyrCO)₂ and Pd(PyrCO)₂ complexes were used in for in vitro cytotoxicity assays using two different etiology human cancer cell lines HeLa and WiDr cells. Investigated compounds showed cytotoxicity levels at or above cisplatin. Pt(DECO)₂ was also tested in vivo in healthy C57BL/6 mice. The complex was adminis

SUBMITTER: Dannen SD 

PROVIDER: S-EPMC7518941 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature