CD163 deficiency facilitates lipopolysaccharide-induced inflammatory responses and endotoxin shock in mice.

ABSTRACT:

Objectives

Septic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it is known that increased serum levels of CD163 are observed in septic/endotoxin shock patients, the exact function and significance of CD163 in macrophage activation remain unclear. Therefore, in the current study, we tested whether CD163 contributes to the pathogenesis of endotoxin shock in mice.

Methods and results

In samples obtained from autopsy, the number of CD163-positive macrophages was increased in the kidney, liver, heart, bone marrow and spleen of patients who had died from septic/endotoxin shock when compared to patients who had died from other causes. The animal study revealed a significantly lower survival rate in CD163-deficient mi

SUBMITTER: Fujiwara Y 

PROVIDER: S-EPMC7518957 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature