Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland.

ABSTRACT: Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of them. Overall mortality was 33%.

SUBMITTER: Coste AT 

PROVIDER: S-EPMC7518979 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature