Evaluation of the risk of acute kidney injury with the use of piperacillin/tazobactam among adult critically ill patients.

ABSTRACT:

Purpose

Piperacillin/tazobactam (PT), when combined with vancomycin, is associated with an increased risk of acute kidney injury (AKI). It is not known whether PT alone is associated with a higher incidence of AKI compared to other β-lactams among critically ill patients. The objective of this study was to compare the incidence of AKI associated with the use of PT to other β-lactams among adult critically ill patients METHODS: This retrospective study was conducted in the surgical and the medical intensive care units at two hospitals within Hamad Medical Corporation (HMC) in Qatar and included adult critically ill patients who received at least one dose of anti-pseudomonal β-lactams. The primary outcome was acute kidney injury, defined using the Kidney Disease Improving Global Outc

SUBMITTER: Saad MO 

PROVIDER: S-EPMC7518983 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature