Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017.

ABSTRACT:

Objective

Combination antiretroviral therapy (cART) has markedly increased survival and quality of life in people living with HIV. With the advent of new treatment options, including single-tablet regimens, durability and efficacy of first-line cART regimens are evolving.

Methods

We analyzed data from the prospective multicenter German Clinical Surveillance of HIV Disease (ClinSurv) cohort of the Robert-Koch Institute. Kaplan-Meier and Cox proportional hazards models were run to examine the factors associated with treatment modification. Recovery after treatment initiation was analyzed comparing pre-cART viral load and CD4+ T-cell counts with follow-up data.

Results

We included 8788 patients who initiated cART between 2005 and 2017. The sample population was predomina

SUBMITTER: Stecher M 

PROVIDER: S-EPMC7519003 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature