Circulation of gut-preactivated naive CD8⁺ T cells enhances antitumor immunity in B cell-defective mice.

ABSTRACT: The gut microbiome has garnered attention as an effective target to boost immunity and improve cancer immunotherapy. We found that B cell-defective (BCD) mice, such as µ-membrane targeted deletion (µMT) and activation-induced cytidine deaminase (AID) knockouts (KOs), have elevated antitumor immunity under specific pathogen-free but not germ-free conditions. Microbial dysbiosis in these BCD mice enriched the type I IFN (IFN) signature in mucosal CD8⁺ T cells, resulting in up-regulation of the type I IFN-inducible protein stem cell antigen-1 (Sca-1). Among CD8⁺ T cells, naïve cells predominantly circulate from the gut to the periphery, and those that had migrated from the mesenteric lymph nodes (mLNs) to the periphery had significantly higher expression of Sca-1. The gu

SUBMITTER: Akrami M 

PROVIDER: S-EPMC7519229 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature