Personalized four-category staging for predicting prognosis in patients with small bowel Adenocarcinoma: an international development and validation study.

ABSTRACT:

Background

Log odds of positive lymph nodes (LODDS) classification showed superiority over 8^th edition N staging in predicting survival of small bowel adenocarcinoma (SBA) patients. The aim of this study was to develop and validate the Tumor, LODDS, and Metastasis (TLM) staging of SBA.

Methods

Totally 1789 SBA patients from the Surveillance, Epidemiology, and End Results (SEER) database between 1988-2010, 437 patients from SEER database between 2011-2013 and 166 patients from multicenters were categorized into development, validation and test cohort, respectively. The TLM staging was developed in the development cohort using Ensemble Algorithm for Clustering Cancer Data (EACCD) method. C-index was used to assess the performance of the TLM staging in predicting can

SUBMITTER: Dai ZH 

PROVIDER: S-EPMC7519244 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature