Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients.

ABSTRACT: Clinical studies combining radiation and immunotherapy have shown promising response rates, strengthening efforts to sensitize tumors to immune-mediated attack. Thus, there is an ongoing surge in trials using preconditioning regimens with immunotherapy. Yet, due to the scarcity of resected tumors treated in situ with radiotherapy, there has been little investigation of radiation's sole contributions to local and systemic antitumor immunity in patients. Without this access, translational studies have been limited to evaluating circulating immune subsets and systemic remodeling of peripheral T cell receptor repertoires. This constraint has left gaps in how radiation impacts intratumoral responses and whether tumor-resident T cell clones are amplified following treatment. Therefore, to interr

SUBMITTER: Chow J 

PROVIDER: S-EPMC7519245 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature