Depth-resolved imaging of photosensitizer in the rodent brain using fluorescence laminar optical tomography.

ABSTRACT: Previous studies have been performed to image photosensitizers in certain organs and tumors using fluorescence laminar optical tomography. Currently, no work has yet been published to quantitatively compare the signal compensation of fluorescence laminar optical tomography with two-dimensional (2-D) imaging in tissues. The purpose of this study is to quantify the benefit that fluorescence laminar optical tomography holds over 2-D imaging. We compared fluorescence laminar optical tomography with maximum intensity projection imaging to simulate 2-D imaging, as this would be the most similar and stringent comparison. A capillary filled with a photosensitizer was placed in a phantom and ex vivo rodent brains, with fluorescence laminar optical tomography and maximum intensity projection images

SUBMITTER: Gaitan B 

PROVIDER: S-EPMC7519352 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature