Determination of CagA EPIYA motif in Helicobacter pylori strains isolated from patients with digestive disorder.

ABSTRACT: This study was conducted to identify patterns of cagA EPIYA motifs in H. pylori strains isolated from patients with gastrointestinal diseases in Hospitals of Shahrekord, and investigate the association between these biomarkers and clinical outcomes of gastrointestinal diseases due to H. pylori. In this study, 253 patients with gastrointestinal diseases were studied within 1395-1396. Histopathological investigations and urease test showed that 207 isolates were H. pylori-positive. Then, screening using a molecular technique, PCR, confirmed that 159 isolates had cagA. Finally, the pattern and prevalence of the motifs were determined by PCR and identified a number of motifs were sequenced. Results of this study showed that the pattern of motifs

SUBMITTER: Khaledi M 

PROVIDER: S-EPMC7519360 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature