Structural brain correlates of dementia in Huntington's disease.

ABSTRACT:

Background

Huntington's disease (HD) is a fatal genetic neurodegenerative disorder with no effective treatment currently available. Progressive basal ganglia and whole-brain atrophy and concurrent cognitive deterioration are prototypical aspects of HD. However, the specific patterns of brain atrophy underlying cognitive impairment of different severity in HD are poorly understood. The aim of this study was to investigate the specific structural brain correlates of major cognitive deficits in HD and to explore its association with neuropsychological indicators.

Participants

Thirty-five symptomatic early-to-mild HD patients and 15 healthy controls (HC) with available T1-MRI imaging were included in this study.

Methods

In this cross-sectional study, HD patients were clas

SUBMITTER: Martinez-Horta S 

PROVIDER: S-EPMC7519361 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature