Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches.

ABSTRACT:

Background

Ovarian cancer is the second fatal malignancy of the female reproductive system. Based on the cancer stem cell (CSC) theory, its poor prognosis of ovarian cancer attributed to tumor recurrence caused by CSCs. A variety of cell surface-specific markers have been employed to identify ovarian cancer stem cells (OCSCs). In this study, we attempted to explore the common feature in ovarian cancer stem cells sorted by multiple approaches.

Methods

We collected the gene expression profiles of OCSCs were from 5 public cohorts and employed R software and Bioconductor packages to establish differently expressed genes (DEGs) between OCSCs and parental cells. We extracted the integrated DEGs by protein-protein interaction (PPI) network construction and explored potential treatm

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7519480 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature