ADIPOQ single nucleotide polymorphisms and breast cancer in northeastern Mexican women.

ABSTRACT:

Background

Adiponectin gene (ADIPOQ) polymorphisms have been shown to affect adiponectin serum concentration and some have been associated with breast cancer (BC) risk. The aims of this study were to describe the frequency of single nucleotide polymorphisms (SNPs) of ADIPOQ in Mexican women with BC and to determine if they show an association with it.

Methods

DNA samples from 397 patients and 355 controls were tested for the ADIPOQ gene SNPs: rs2241766 (GT) and rs1501299 (GT) by TaqMan allelic discrimination assay. Hardy-Weinberg equilibrium (HWE) was tested. Multiple SNP inheritance models adjusted by age and body mass index (BMI) were examined for the SNP rs1501299.

Results

We found that in the frequency analysis of rs1501299 without adjusting the BMI and age, the g

SUBMITTER: Cerda-Flores RM 

PROVIDER: S-EPMC7519484 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature