Comparative transcriptomic analysis of Rickettsia conorii during in vitro infection of human and tick host cells.

ABSTRACT:

Background

Pathogenic Rickettsia species belonging to the spotted fever group are arthropod-borne, obligate intracellular bacteria which exhibit preferential tropism for host microvascular endothelium in the mammalian hosts, resulting in disease manifestations attributed primarily to endothelial damage or dysfunction. Although rickettsiae are known to undergo evolution through genomic reduction, the mechanisms by which these pathogens regulate their transcriptome to ensure survival in tick vectors and maintenance by transovarial/transstadial transmission, in contrast to their ability to cause debilitating infections in human hosts remain unknown. In this study, we compare the expression profiles of rickettsial sRNAome/transcriptome and determine the transcriptional start sites (TSS

SUBMITTER: Narra HP 

PROVIDER: S-EPMC7519539 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature