The evolution of TNF signaling in platyhelminths suggests the cooptation of TNF receptor in the host-parasite interplay.

ABSTRACT:

Background

The TNF signaling pathway is involved in the regulation of many cellular processes (such as apoptosis and cell proliferation). Previous reports indicated the effect of human TNF-α on metabolism, physiology, gene expression and protein phosphorylation of the human parasite Schistosoma mansoni and suggested that its TNF receptor was responsible for this response. The lack of an endogenous TNF ligand reinforced the idea of the use of an exogenous ligand, but also opens the possibility that the receptor actually binds a non-canonical ligand, as observed for NGFRs.

Methods

To obtain a more comprehensive view, we analyzed platyhelminth genomes deposited in the Wormbase ParaSite database to investigate the presence of TNF receptors and their respective ligands. Using dif

SUBMITTER: Bertevello CR 

PROVIDER: S-EPMC7519573 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature