Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice.

ABSTRACT: Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer's disease and several other neurodegenerative diseases, called tauopathies. Recent studies have revealed that propagation of assembled tau is key to understanding the pathological mechanisms of these diseases. Mouse models of tau propagation are established by injecting human-derived tau seeds intracerebrally; nevertheless, these have a limitation in terms of regulation of availability. To date, no study has shown that synthetic assembled tau induce tau propagation in non-transgenic mice. Here we confirm that dextran sulphate, a sulphated glycosaminoglycan, induces the assembly of recombinant tau protein into filaments in vitro. As compared to tau filaments induced by heparin, those in

SUBMITTER: Masuda-Suzukake M 

PROVIDER: S-EPMC7519727 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature