Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder.

ABSTRACT: Ongoing neuroinflammation may contribute to symptoms of autism spectrum disorder (ASD) in at least a portion of affected individuals. Mesenchymal stromal cells (MSCs) have demonstrated the capacity to modulate neuroinflammation, but safety and feasibility of MSC administration in children with ASD have not been well established. In this open-label, phase I study, 12 children with ASD between 4 and 9 years of age were treated with intravenous (IV) infusions of human cord tissue mesenchymal stromal cells (hCT-MSCs), a third-party MSC product manufactured from unrelated donor umbilical cord tissue. Children received one, two, or three doses of 2 × 10⁶ cells per kilogram at 2-month intervals. Clinical and laboratory evaluations were performed in person at baseline and 6 months and r

SUBMITTER: Sun JM 

PROVIDER: S-EPMC7519773 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature