Therapeutic Anticoagulation Delays Death in COVID-19 Patients: Cross-Sectional Analysis of a Prospective Cohort.

ABSTRACT: A hypercoagulable state has been described in coronavirus disease 2019 (COVID-19) patients. Others have reported a survival advantage with prophylactic anticoagulation (pAC) and therapeutic anticoagulation (tAC), but these retrospective analyses have important limitations such as confounding by indication. We studied the impact of tAC and pAC compared with no anticoagulation (AC) on time to death in COVID-19. We performed a cross-sectional analysis of 127 deceased COVID-19 patients and compared time to death in those who received tAC ( n  = 67), pAC ( n  = 47), and no AC ( n  = 13). Median time to death was longer with higher doses of AC (11 days for tAC, 8 days for pAC, and 4 days for no AC, p  < 0.001). In multivariate analysis, AC was associated with longer t

SUBMITTER: Ionescu F 

PROVIDER: S-EPMC7519875 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature